Human CD155 Protein, Fc tag

 

Catalog Number:

Y65B99

Description:

Human CD155 expressed on antigen‐presenting cells or tumor cells binds to ITIM domains (TIGIT) to down‐regulate T cell and natural killer (NK) cell functions. A recombinant form (Val 29 – Asn 343) of CD155 protein (GenBank: NP_006496.4) fused with human IgG1 Fc (Fc) tag at the C-terminus was produced by human embryonic kidney HEK cells, followed by purification. The purity has been examined as determined >95% by reducing SDS-PAGE, where protein with a calculated MW of ~ 64 kDa (including tags) migrates as 62-98 kDa. We evaluated its binding to TIGIT protein (Cat.No. U37J55) in ELISAs, see results.

Protein Synonyms:

PVR, FLJ25946, PVS, TAGE4, HVED, NECL5

Applications:

Crystallization (Crys), ELISA, SDS-PAGE (SDS), Western Blotting (WB), Immunization or Antibody Sorting Probe, and other biological assays

Source:

Human embryonic kidney HEK cells

Species:

Human

Sequence:

Val 29 – Asn 343

Tag:

human IgG1 Fc

Size and Formulation:

100 or 500 μg in PBS, pH7.2, without preservatives.

Note: Not lyophilized formulation, so no lyophilized protectant reagents added.

Endotoxin:

Less than 1.0 EU per μg by the LAL method / rFC method.

Shipping or storage condition

Ship with dry ice. Recommend -80°C storage for long-term. Store at 4°C or −20 °C for short-term.  Multiple freeze/Thaw cycles will reduce its activity. Aliquot is recommended.

Note:

For research use only.