Anti-Ebola Glycoprotein Base Monoclonal Neutralizing Antibody (KZ52)
Catalog Number:
Y90H86
Clone:
KZ52
Description:
This antibody was derived from a human survivor of the 1995 Kikwit outbreak of Ebola, and binds to the Ebola virus surface glycoprotein in its trimeric, pre-fusion conformation (GP1+GP2). KZ52 recognizes a protein epitope at the chalice base where it clamps several regions of the pre-fusion GP2 to the amino terminus of GP1. This antibody neutralizes Zaire ebolavirus in vitro by preventing rearrangement of the GP2 HR1A/HR1B segments and blocking host membrane insertion of the internal fusion loop. Alternatively, IgG KZ52 may sterically hinder access to the RBS or to a separate binding site of another cellular factor, especially if multiple attachment events are required for entry (Lee et al. 2009).
Epitope:
Base of Ebola GP
Clonality and isotype:
Monoclonal antibody human IgG1
Specificity:
Ebola
Form:
Liquid in PBS, pH7.2, without preservatives
Storage:
Shipped at ambient temperature. Stored at 4 °C.
Purification:
Cell culture supernatant followed by filtration and Protein A purification
Applications:
IF, WB, ELISA, IHC, IP et al.
Conjugate:
Unconjugated
Product Usage Statement:
This product is intended for research use only.
