Rhabdovirus-CHPV, Rabies, VSV

Chandipura virus (CHPV) is a member of the family Rhabdoviridae and genus Vesiculovirus. CHPV causes acute encephalitis in human paediatric populations. The structural protein glycoprotein (G) enables virus adsorption, assembly, budding and also elicits an antibody response thus acting as a major antigenic determinant.

Rabies virus (RABV) is a member of the family Rhabdovirus (Rhabdoviridae). Rabies virus has a broad host range with the capacity to infect almost all mammals. Untreated rabies infections are nearly 100% fatal, causing 50,000 to 60,000 human deaths annually and significantly affecting animal populations. The rabies virus glycoprotein (RABV-G) is the only surface-exposed protein on the virus and is the target of vaccine-elicited neutralizing antibodies.

Vesicular stomatitis virus (VSV) belongs to the Vesiculovirus genus of the family Rhabdoviridae. As a well-studied livestock pathogen, it has been used for gene delivery or vaccine (e.g. ERVEBO, rVSVΔG-ZEBOV-GP) in human. VSV is a bullet-shaped, enveloped virus consisting of a single strand of negative-sense RNA, which encodes five major proteins. The simplicity of VSV genome enables its extensively application in research field.